Package: MPGE Type: Package Title: A Two-Step Approach to Testing Overall Effect of Gene-Environment Interaction for Multiple Phenotypes Version: 1.0.1 Date: 2026-03-09 Authors@R: c(person("Arunabha", "Majumdar", email = "statgen.arunabha@gmail.com", role = c("aut", "cre")), person("Tanushree", "Haldar", email = "tanushree.haldar@gmail.com", role = "aut")) Maintainer: Arunabha Majumdar Description: Interaction between a genetic variant (e.g., a single nucleotide polymorphism) and an environmental variable (e.g., physical activity) can have a shared effect on multiple phenotypes (e.g., blood lipids). We implement a two-step method to test for an overall interaction effect on multiple phenotypes. In first step, the method tests for an overall marginal genetic association between the genetic variant and the multivariate phenotype. The genetic variants which show an evidence of marginal overall genetic effect in the first step are prioritized while testing for an overall gene-environment interaction effect in the second step. Methodology is available from: A Majumdar, KS Burch, T Haldar, S Sankararaman, B Pasaniuc, WJ Gauderman, JS Witte (2020) . Depends: R (>= 3.5.0) License: GPL-3 Encoding: UTF-8 LazyData: true URL: https://github.com/ArunabhaCodes/MPGE BugReports: https://github.com/ArunabhaCodes/MPGE/issues RoxygenNote: 7.3.3 Roxygen: list(markdown = TRUE) Suggests: knitr, rmarkdown, spelling, testthat (>= 3.0.0) VignetteBuilder: knitr Imports: car, purrr, stats, utils Config/testthat/edition: 3 Language: en-US Config/pak/sysreqs: cmake make libicu-dev Repository: https://arunabhacodes.r-universe.dev Date/Publication: 2026-03-13 05:42:14 UTC RemoteUrl: https://github.com/arunabhacodes/mpge RemoteRef: HEAD RemoteSha: 090da3655d8653eaa5186878760738a6004949c0 NeedsCompilation: no Packaged: 2026-06-11 09:16:52 UTC; root Author: Arunabha Majumdar [aut, cre], Tanushree Haldar [aut]